基于核酸治疗的药物的前景Pharmaceutical Perspectives of Nucleic acid-based Therapeutics

作者简介

Emphasizing its uses in cancer and cardiovascular and autoimmune diseases, Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the  in vivo delivery of nucleic acids, the genesis of structure-synthesis-function interrelationships and the evolutionary approaches of these gene carriers. The book also addresses the influence of a viable gene expression system on disease by controlling gene regulation, transcription, translation and replication.

书籍目录

List of color platesList of figuresList of tablesList of contributorsForewordPreface1 Basic components of gene expression plasmids2 Inducible gene expression strategies in gene therapy3 Modulation of gene expression by antisense oligonucleotides4 Ribozymes as therapeutic agents and genetic tools5 Peptide nucleic acids (PNA) binding-mediated target gene transcription6 Aptamers for controlling gene expression7 Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy8 Compaction and condensation of DNA9 Structure, dispersion stability and dynamics of DNA and polycation complexes10 Structure and structure-activity correlations of cationic lipid/DNA complexes: supramolecular assembly and gene delivery11 Cellular uptake, metabolic stability and nuclear translocation of nucleic acids12 Nucleocytoplasmic trafficking13 Optimizing RNA export for transgene expression14 Naked plasmid DNA delivery of a therapeutic protein15 Cationic lipid-based gene delivery16 Peptide-based gene delivery systems17 Cationic and non-condensing polymer-based gene delivery18 Device-mediated gene delivery19 Basic pharmaeokinetics of oligonucleotides and genes20 Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors21 Hepatic delivery of nucleic acids using hydrodynamics-based procedure22 Role of CpG motifs in immunostimulation and gene expression23 Local cardiovascular gene therapy24 Gene therapy for cardiovascular disease25 Gene therapy for the prevention of autoimmune diabetes  List of color plates

内容概要

Ram Mahato is at the University of Tennessee in Memphis, USA and Sung Wan Kim is at the University of Utah, USA.

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