Biochemistry-生物化学

作者简介

《医学教育改革系列教材:生物化学》汇集名师，各主编均由卫生部规划的五年制、八年制教材的主编担任。适合国情，教材的编写内容和体系主要参考我国医学院校长期使用并多次修订的五年制、八年制规划教材，更符合我国的教学模式。语言纯正，根据引进的经典英文原版教材改编，聘请国外作者或编辑参与审校工作。

书籍目录

Chapter1 Molecular Compositions of Protdns 1.1 Molecular Compositions of Proteins 1.2 Protein Structure 1.3 Protein Structure and Function 1.4 Protein Physicochemical Properties  1.5 Classification of Proteins Chapter2 Nucleic Acids 2.1 Nucleotides and Nucleic Acids 2.2 Spatial Structure and Function of DNA 2.3 Spatial Structure and Function of RNA 2.4 Physicochemical Properties of Nucleic Acids Chapter3 Enzymes 3.1 Structures and Properties of Enzymes  3.2 Enzymatic Kinetics 3.3 Regulation of Enzymes 3.4 Medical Aspects of Enzymes  Chapter4 Metabolism of Carbohydrates 4.1 Overview 4.2 Glycolysis and Anaerobic Oxidation of Glucose 4.3 Aerobic Oxidation of Glucose 4.4 Pentose Phosphate Pathway  4.5 Gluconeogenesis 4.6 Glycogen Catabolism Chapter5 Lipid Metabolism 5.1 Overview 5.2 Triglyceride Metabolism 5.3 Phospholipid Metabolism 5.4 Cholesterol Metabolism  5.5 Lipid Transportation in Plasma Chapter5 Biological Oxidation 6.1 Electron Carriers and Electron Transport Chain 6.2 Oxidative Phosphorvlation  6.3 Shuttle Systems 6.4 Mitochondrial Diseases Chapter7 Amino Acid Metabolism 7.1 Requirement of Protein/Amino Acids  7.2 Protein Digestion，Absorption and Putrefaction 7.3 Amino Acid Metabolic Pool 7.4 General Pathways of Amino Acid Catabolism 7.5 Metabolism of Individual Amino Acids Chapter8 Metabolism of Nucleotides 8.1 Metabolism of Purine Nucleotides 8.2 Metabolism of Pyrimidine Nucleotides 8.3 Conversion of Nucleotides  8.4 Nucleotide Metabolism Related to Medicine Chapter9 Regulation and Integration of Metabolism 9.1 Characteristics of Metabolism  9.2 Interconversion of Metabolic Pathways  9.3 Regulation of Metabolisms Chapter10 DNA Biosynthesis 10.1 DNA-dependent DNA Synthesis(Replication) 10.2 RNA-dependent DNA Svnthesis(Reverse Transcription) 10.3 DNA Damage and Repair Chapter11 RNA Biosynthesis 11.1 RNA Biosynthesis(Transcription) 11.2 RNA Post-transcriptional Processing Chapter12 Protein Biosynthesis,Sorting and Targeting 12.1 Protein Synthesis System 12.2 Protein Synthesis in Prokaryotes  12.3 Protein Synthesis in Eukaryotes 12.4 Protein Sorting and Targeting 12.5 Clinical Relevancies of Protein Synthesis Chapter13 Biochemistry of Blood 13.1 Composition and Functions of the Blood 13.2 Plasma Proteins 13.3 Blood Cell Metabolism Chapter14 Biochemistry of the Liver 14.1 Metabolic Roles of the Liver 14.2 Biotransformation in the Liver  14.3 Metabolism of Bile Acids 14.4 Bile Pigment Metabolism

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《医学教育改革系列教材:生物化学》由高等教育出版社出版。

章节摘录

版权页：   插图：   1.4.2 Protein Solution Behaves Colloid PropertyProteins are polymers with molecular weights generallyin 10-1,000KD.According to the measurementknowledge,for example,a globular protein withmolecular weight of 34.5KD,the particle diameteris 4.3nm.Therefore,the particle diameter of proteinmolecules are generally in 1-100nm,forming acolloidal solution in water,with a Tyndall phenomenon,Brownian motion.not through a semipermeable membrane,slower diffusion,greater viscosity etc. Proteins contain many hydrophilic groups suchas amino,carboxyl,hydroxyl,thiol and amidegroup on the surface,which form a hydration shellwith water molecules to separate the particles ofprotein molecules with each other.In addition,proteinscarrying the same type of charges make electricrepulsion.Hydration shell and electric repulsionmake proteins stable in solution. 1.4.3 Proteins may Undergo Denaturationand Rena tura tion The process in which a protein loses its native conformationunder the treatment of denaturants iscalled protein denaturation.The denaturants includephysical factors such as heat,ultraviolet light,violent shaking,and chemical factors such as strongacids,bases,organic solvents and detergents.A lossof three dimensional structure is sufficient to causechange of physical and chemical properties and binlogical characteristics of proteins,loss of function,but does not affect the primary structure of proteins.Denaturation is essentially the breakage ofnoncovalent bond(hydrogen bond,ionic bond,hydrophobic interactions,etc.).The denatured proteins tend to decrease in solubility.increase the viscosity,and lose the biological activity.Denaturationof some proteins is reversible.

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