医药化学

作者简介

《医药化学(影印本)(先锋版)》由科学出版社出版。

书籍目录

AbbreviationsPrefaceAbout the authorSection A-The science of medicinal chemistry　A1 Introduction　A2 From concept to marketSection B-Drug targets　B1 Enzymes　B2 Receptors　B3 Carrier proteins　B4 Structural proteins　B5 Nucleic acids　B6 Lipids　B7 CarbohydratesSection C-Pharmacokinetics　C1 Pharmacokinetics　C2 Drug absorption　C3 Drug distribution　C4 Drug metabolism　C5 Drug excretion　C6 Drug administration　C7 Drug dosingSection D-Biological testing and bioassays　D1 Testing drugs　D2 Testing drugs in uitro　D3 Testing drugs in uiuoSection E-Drug discovery　E1 The lead compound　E2 Natural sources of lead compounds　E3 Synthetic sources of lead compoundsSection F-Synthesis　F1 Synthetic considerations　F2 Stereochemistry　F3 Combinatorial synthesisSection G-Structure-activity relationships　G1 Definition of structure-activity relationshiips　G2 Binding interactions　G3 Functional groups as binding groups　G4 The pharmacophore　G5 Quantitative structure-activity relationshipsSection H-Target orientated drug design 　H1 Aims of drug design　H2 Computer aided drug design　H3 Simplification of complex molecules　H4 Conformational restraint　H5 Extra binding interactions　H6 Enhancing existing binding interactionsSection I-Pharmacokinetic orientated drug design　I1 Drug solubility　I2 Drug stabilitySection J-Patenting and manufacture　J1 Patenting and chemical development　J2 Optimization of reactions　J3 Scale-up issues　J4 Process development　J5 SpecificationsSection K-Preclinical testing and clinical trials　K1 Toxicology　K2 Pharmacology and pharamceutical chemistry　K3 Drug metabolism studies　K4 Clinical trials　K5 Regulatory affairsSection L-Case study:inhibitors of EGF-receptor kinase　L1 Epidermal growth factor receptor　L2 Testing procedures　L3 From lead compound to dianilino-phthalimides　L4 Modeling studies　L5 4-(Phenylamino)pyrrolopyrimidines　L6 PyrazolopyrimidinesSection M-History of medicinal chemistry　M1 The age of herbs,potions and magic　M2 The nineteenth century　M3 A fledgling science(1900-1930)　M4 The dawn of the antibacterial age(1930-1945)　M5 The antibiotic age(1945-1970s)　M6 The age of reason (1970s to present)Further readingIndex

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